It is important to take naltrexone as prescribed, about one to two hours before drinking, and adhere to safe drinking guidelines. Drinking without proper dosing or supervision reduces the method’s effectiveness and poses health risks. Always consult a healthcare provider to ensure the treatment plan aligns with your goals.
Early life

Some participants grow impatient if they want rapid transformation or if their drinking is causing immediate crises. TSM must be coupled with enough life stability to allow the extended timeline. Reduces Relapse AnxietyRelapse in standard abstinence-based programs often leads to guilt or a sense of failure, potentially derailing progress. With TSM, “lapses” are built into the framework—drinking is expected to continue, but always with medication. This approach can mitigate the black-and-white “I blew it” mentality common in relapse scenarios.
How to Take Naltrexone
Naltrexone, the primary medication in the Sinclair Method, is considered safe when combined with many common medications, including antidepressants. However, it’s important to consult with a healthcare provider before combining naltrexone with other medications, as their interactions with certain drugs, particularly those affecting the liver or the central nervous system. A healthcare provider helps monitor for potential interactions and ensure that all medications work together effectively and safely.
Does Naltrexone Block Pleasure from Other Activities?
Since then, it has been widely used as part of a comprehensive treatment plan for people seeking to reduce alcohol consumption and regain control over their drinking behavior. TSM is an evidence-based treatment for Alcohol Use Disorder (AUD) that uses naltrexone to gradually reduce alcohol cravings over time. Unlike traditional abstinence-based methods, TSM allows people to keep drinking while retraining their brain to unlearn compulsive alcohol use. TSM is a medication-based approach that helps people gradually regain control over their drinking. It works by using naltrexone, a prescription medication that blocks the brain’s pleasurable response to alcohol when taken before drinking. Over time, this helps reduce cravings and weaken habitual drinking patterns.
If you have specific concerns or a situation arises in which you require medical advice, you should consult with an appropriately trained and qualified medical services provider. Examples of such groups are Alcoholics Anonymous (AA) and other 12-step programs. Knowledge of alcohol’s effects on the brain has paved the way for drug-based therapies. Skypoint Recovery focuses exclusively on men, creating a supportive environment designed to empower lasting recovery. Our team is here to help you figure out what works best for you, from treatment programs to payment strategies. Some individuals notice significant changes in a few months, while others require a year or more of continued use.
Nurses at the bedside or in outpatient settings may be the first caregivers to speak to a patient who has decided to seek help. The group members share alcohol-related problems and help each other voluntarily. Joining these groups will be more effective if combined with professional-led treatments. Those who take naltrexone should inform their doctors, surgeons, or dentists.

In fact, part of its success can be attributed to its gradual approach. By slowly reducing alcohol consumption, people are less likely to experience serious alcohol withdrawal symptoms, including delirium tremens (DT). It’s alcoholism symptoms also beneficial because it lets people be actively involved in their treatment, which can help them feel more in control of their drinking and recovery. Furthermore, the Sinclair Method is much more affordable than more intensive and costly rehabilitation centers. Alcohol addiction is a pervasive issue that affects millions of individuals worldwide.
- Involvement of spouses or parents in psychoeducation can reduce conflicts and better support the TSM approach at home.
- Before we assess its effectiveness, it’s crucial to understand what TSM entails.
- A doctor can provide a proper diagnosis, prescribe naltrexone, monitor your progress, and offer support throughout the treatment process.
What are the Steps Involved in TSM?
Some people report significant improvements within 2-3 months, while others might need up to a year to see substantial changes. It’s important to remember that TSM is a gradual process that requires patience and consistency. The key is sustained use of naltrexone before drinking to reduce cravings, with the ultimate goal of changing the brain’s association between alcohol and pleasure.
If you want to stop drinking immediately, this method may not be for you. ATSM is suitable for individuals diagnosed with AUD who have not found success with abstinence-based treatments or are looking for an alternative approach. It’s important to consult with a healthcare professional to determine if TSM is appropriate for your situation. Nevertheless, Dr. Sinclair’s work laid the foundation for a new approach to addiction treatment, emphasizing the potential of medication-assisted therapy to change the way individuals relate to alcohol. His legacy is The Sinclair Method—a testament to the power of scientific inquiry to challenge conventions and offer hope to those struggling with AUD. It challenges deeply entrenched beliefs about addiction recovery, sparking debate and skepticism among traditionalists.
- So, how do you know if you should try the Sinclair Method (and naltrexone)?
- When naltrexone is in the body, the dopamine-driven euphoric rush is diminished, which reduces cravings for pleasurable seeking drugs, specifically alcohol and opioids.
The Sinclair Method is an option if you want to reduce your drinking, but don’t necessarily want to abstain from alcohol altogether. The truth is, decoupling the Sinclair method pleasurable effects of alcohol from drinking is like using a weed whacker on your garden. You may have the appearance of having cleaned things up, but unless you’ve pulled those weeds from the roots, they can easily reemerge and wreak havoc later on. The expectation was that a less rewarding effect from alcohol overtime would condition the brain to drink less frequently and in smaller amounts (so, reducing binge behavior). More serious side effects can include mental health changes, like worsening depression or suicidal ideation, as well as liver problems.